Our Collective Hearts

Optimism, Persistence, and Our Collective Crystal Ball

Thank you indeed to Christopher Plowe for the very generous introduction—I think it was perhaps too generous. Chris showed the list of fellows and students who have worked with me at National Institutes of Health (NIH), and great credit really goes to them. I have been fortunate and privileged to have been surrounded by the brilliance of all of these individuals and their accomplishments throug...

When monocytes come (too) close to our hearts.

Cooling heads and hearts versus cooling our heels.

Evidence suggests that full implementation of therapeutic hypothermia after cardiac arrest could save thousands of lives each year. Critical unanswered questions persist, beginning with a lack of evidence in regard to how early cooling should be initiated, which cooling strategy is most effective at cooling the brain, and, ultimately, what method of cooling is most optimal for survival. Two rep...

A nucleolar weapon in our fight for regenerating adult hearts: nucleostemin and cardiac stem cells.

Ischemic diseases and heart failure remain the major causes of morbidity and mortality in the industrialized world. Several new therapeutic modalities have been developed to interfere with the response to injury and to improve cardiac function after ischemia or cardiomyopathy. Experimental and clinical studies demonstrated that the transplantation of bone marrow–derived or tissue-resident stem/...

Our hearts were once young and gay: health care rationing and the elderly.